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IBS irritable bowel syndrome ; , 101, 337 Ibugel medication ; , 257 ibuprofen cream medication, 257 HSG procedure, 132 overview, 192193, 248 painful periods, 94 prescription varieties, 250 ice pack, 205 identical twin, 61 Iknoian, Therese T'ai Chi For Dummies ; , 236 ileus, 207 imagination, 329 imipramine, 279, 280 immune system allergic reaction, 6970 danazol treatment, 183 endometriosis causes, 6571 foods to boost, 296 future treatments, 196 link to endometriosis, 242 negative brain activity, 288 immunoglobulin, 125, 337 immunotherapy biologic response modifiers, 244 definition, 337 future advances, 324 overview, 242243 implant. See also lesion danazol treatment, 183 definition, 11 effects, 4454 infertility treatment, 137139 intestinal endometriosis, 99 in vitro fertilization IVF ; advantages, 140 drawbacks, 141 early-stage endometriosis, 119 LUF remedy, 123 overview, 139.
Malities in two different cutaneous manifestations of venous disease. J Acad Dermatol. 1996; 34: 204-208. Acland KM, Darvay A, Wakelin SH, Russell-Jones R. Livedoid vasculitis: a manifestation of the antiphospholipid syndrome? Br J Dermatol. 1999; 140: 131135. Winkelmann RK, Schroeter AL, Kierland RR, Ryan TM. Clinical studies of livedoid vasculitis segmental hyalinizing vasculitis ; . Mayo Clin Proc. 1974; 49: 746-750. Calamia KT, Balabanova M, Perniciaro C, Walsh JS. Livedo livedoid ; vasculitis and the factor V Leiden mutation: additional evidence for abnormal coagulation. J Acad Dermatol. 2002; 46: 133-137. Drucker CR, Duncan WC. Antiplatelet therapy in atrophie blanche and livedo vasculitis. J Acad Dermatol. 1982; 7: 359-363. McCalmont CS, McCalmont TH, Jorizzo JL, White WL, Leshin B, Rothberger H. Livedo vasculitis: vasculitis or thrombotic vasculopathy? Clin Exp Dermatol. 1992; 17: 4-8. Edirisinghe SP. Homocysteine-induced thrombosis. Br J Biomed Sci. 2004; 61: 40-47. Ball GV, Goldman LN. Chronic ulcerative colitis, skin necrosis, and cryofibrinogenemia. Ann Intern Med. 1976; 85: 464-466. Cohen SJ, Pittelkow MR, Su WP. Cutaneous manifestations of cryoglobulinemia: clinical and histopathologic study of seventy-two patients. J Acad Dermatol. 1991; 25: 21-27. Ferri C, Zignego AL, Pileri SA. Cryoglobulins. J Clin Pathol. 2002; 55: 4-13. Blain H, Cacoub P, Musset L, et al. Cryofibrinogenaemia: a study of 49 patients. Clin Exp Immunol. 2000; 120: 253-260. Heine KG, Davis GW. Idiopathic atrophie blanche: treatment with low-dose heparin. Arch Dermatol. 1986; 122: 855-856. Sauer GC. Pentoxifylline Trental ; therapy for the vasculitis of atrophie blanche. Arch Dermatol. 1986; 122: 380-381. Lee SS, Ang P, Tan SH. Clinical profile and treatment outcome of livedoid vasculitis: a case series. Ann Acad Med Singapore. 2003; 32: 835-839. Hsiao GH, Chiu HC. Livedoid vasculitis: response to low-dose danazol. Arch Dermatol. 1996; 132: 749-751. Klein KL, Pittelkow MR. Tissue plasminogen activator for treatment of livedoid vasculitis. Mayo Clin Proc. 1992; 67: 923-933. Purcell SM, Hayes TJ. Nifedipine treatment of idiopathic atrophie blanche. J Acad Dermatol. 1986; 14: 851-854. Bisalbutra P, Kullavanijaya P. Sulfasalazine in atrophie blanche. J Acad Dermatol. 1993; 28: 275-276. Rustin MHA, Bunker CB, Dowd PM. Chronic leg ulceration with livedoid vasculitis, and response to oral ketanserin. Br J Dermatol. 1989; 120: 101-105. Ravat FE, Evans AV, Russell-Jones R. Response of livedoid vasculitis to intravenous immunoglobulin. Br J Dermatol. 2002; 147: 166-169. Lee JH, Choi HJ, Kim SM, Hann SK, Park YK. Livedoid vasculitis responding to PUVA therapy. Int J Dermatol. 2001; 40: 153-157. Francs C, Barete S. Difficult management of livedoid vasculopathy. Arch Dermatol. 2004; 140: 1011. Hirsh J, Dalen JE, Anderson DR, et al. Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 2001; 119 suppl ; : 8S-21S.
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236. At the time that Bellco i ; refused to provide pedigree documentation or electronic information and ii ; refused to permit Plaintiff to purchase any product from it, it was fully aware that Plaintiff would be entirely unable to obtain any of the Manufacturers' pharmaceutical products from any other source and would, therefore, be forced to discontinue its wholesale operations with respect to those products.
Outputs projects would be published in July and available on the DLU website at publichealth.uwa .au welcome resear ch dlu . Colin Xanthis then gave an interesting presentation on the Health Reform Implementation Taskforce's Information Communications Technology ICT ; Program. A key aim of the program is to implement a single, State-wide centralised and consistent ICT solution that supports and enable the Health Reform Committee's reform agenda. The advantages of such a system from a consumer's perspective include: Streamlined and targeted access to health information; The ability to contribute to their own health information; Streamlined access and entry into the health system; Greater visibility regarding waiting lists and care delivery scheduling; and Greater confidence in the health care sector arising from improved care and protection of personal health information. Colin noted that consumers wouldn't see much happening in this area for about two years, but that hopefully the project would be completed in five to six years. The group emphasised the importance of having consumer representatives on any committees associated with the project. The last component of the forum was a group session facilitated by Amanda Bresnan and Anne McKenzie Board member, HCC ; . While the benefits of electronic health records, such as improved health outcomes and continuity of care, especially for rural and remote consumers were acknowledged, a number of issues of concern remained. These concerns centred on privacy, ownership of records and security, for example and darvon.
None of the commonly prescribed medical therapeutic options is curative and most have undesirable side effects.
Inoid-induced antinociception in the rat; Life Sci 56: 2103; 1995. Maseda C, Hama K, Fukui Y, Matsubara K, Takahashi S, Akane A: Detection of delta-9-THC in saliva by capillary GC ECD after marihuana smoking; Forensic Sci Int 32: 259; 1986. Mason AP, McBay AJ: Cannabis: Pharmacology and interpretation of effects; J Forensic Sci 30: 615; 1985. Mason AP, McBay AJ: Ethanol, marijuana, and other drug use in 600 drivers killed in single-vehicle crashes in North Carolina, 19781981; J Forensic Sci 29: 987; 1984. Mathew RJ, Wilson WH, Melges FT: Temporal disintegration and its psychological and physiological correlates. Changes in the experience of time after marijuana smoking; Ann Clin Psychiatry 4: 235; 1992. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI: Structure of a cannabinoid receptor and functional expression of the cloned cDNA; Nature 346: 561; 1990. Matsunaga T, Iwawaki Y, Watanabe K, Yamamoto I, Kageyama T, Yoshimura H: Metabolism of delta-9tetrahydrocannabinol by cytochrome P450 isozymes purified from hepatic microsomes of monkeys; Life Sci 56: 2089; 1995. Matters RD, Shaw LM, Edling-Owens J, Engelman K, ElSohly MA: Bypassing the first-pass effect for the therapeutic use of cannabinoids; Pharmacol Biochem Behav 44: 745; 1993. Mattes RD, Engelman K, Shaw LM, ElSohly MA: Cannabinoids and appetite stimulation; Pharmacol Biochem Behav 49: 187; 1994. Mattila MJ, Kuitunen T, Veilahti J: Related coordinative, reactive and cognitive performances as impaired by drugs and alcohol: comparison with clinical test for driving fitness; J Traffic Med 21: 101; 1993. McBurney LJ, Bobbie BA, Sepp LA: GC MS and Emit analyses for delta-9-tetrahydrocannabinol metabolites in plasma and urine of human subjects; J Anal Toxicol 10: 56; 1986. McCurdy HH, Callahan LS, Williams RD: Studies on the stability and detection of cocaine, benzoylecgonine, and acid in whole blood using abuscreen radioimmunoassay; J Forensic Sci 34: 858; 1989. McCurdy HH, Lewellen LJ, Callahan LS, Childs PS: Evaluation of the ion trap detector for the detection of 11nor-delta-THC-carboxylic acid in urine after extraction by bonded-phase adsorption; J Anal Toxicol 10: 175; 1986. McGregor IS, Arnold JC, Weber MF, Topple AN, Hunt GE: A comparison of delta-9-THC and anandamide induced c-fos expression in the rat forebrain; Brain Res 802: 19; 1998. McLean S, Parsons RS, Chesterman RB, Dineen R, Johnson MG, Davies NW: Drugs, alcohol and road accidents in Tasmania; Med J Aust 147: 6; 1987. Mechoulam R: Marihuana chemistry; Science 168: 1159; 1970. Mechoulam R: A random walk through a cannabis field; Pharmacol Biochem Behav 40: 461; 1991. Mechoulam R, Feigenbaum JJ, Lander N, Segal M, Jarbe TUC, Hiltunen AJ, Consroe P: Enantiomeric cannab and deltasone.
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That age-related alterations in locomotion might also be altered in these mice K. Itokawa and G. R. Uhl, unpublished results ; . Properties of VMAT2 knockout mice Expression of VMAT2 protein in neonatal brains, measured by saturation analyses of [3H]dihydrotetrabenazine binding, is decreased 50% in heterozygotes compared to wild-type mice and is undetectable in homozygous mice 9 ; . Analyses of offspring of matings between heterozygotes revealed that whereas the expected fractions of homozygous and heterozygous mice emerged at birth, homozygous mice were poorly viable postnatally. Pathological examination of homozygous mice killed on P1 revealed only reduced milk in the stomachs. Heterozygote VMAT2 knockout mice were histologically normal, viable into adult life, gained weight at rates similar to their wild-type littermate controls, and expressed VMAT2 protein levels as examined by binding studies ; about half those of wild-type mice. Although expression of at least some VMAT2 is thus necessary for good viability past the immediate postnatal period, mice with half the wild-type levels of VMAT2 expression are able to develop and display many normal baseline behaviors that include complex reproductive behaviors. Most heterozygous knockout mice with half of wild-type levels of VMAT2 expression are viable into adult life. However, 10 15% of these animals die suddenly between 2 and 4 months of age without apparent antecedents 9, 12 ; . Cardiovascular effects Anesthetized mice: heart rate, blood pressure, and baseline behaviors Heterozygous mice reveal heart rates, systolic, diastolic, and mean femoral arterial blood pressures greater than those of wild-type mice when assessed under anesthesia using femoral catheters 9 ; . They are similar to wild-type mice in expression of a previously conditioned passive avoidance habit, stress responses emitted in a stressful novel environment, the ability to hang onto an inverted screen, and gross locomotor activity measured under bright illumination. Freely moving mice: heart rates and conduction intervals To further explore cardiovascular parameters in mice free from anesthesia and assess possible mechanisms for the apparent sudden death that afflicts as many as 10 15% of the heterozygotes in their second and third months of life, we telemetered EKG data from these mice 12 ; . Freely moving mice with and desyrel!
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Malcolm Maclure, Michael Allen, Rosemary Bacovsky, Shawn Bugden, Harold Lopatka, Kyle MacNair, Richard Morrow, Anne Nguyen, Loren Regier. A project of the Canadian Academic Detailing Collaboration and Drug Policy Futures.
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The Independent Drug Information Service iDiS ; is supported by the PACE Program of the Department of Aging of the Commonwealth of Pennsylvania, and is not affiliated in any way with any pharmaceutical company. These are general recommendations only; specific clinical decisions should be made by the treating physician based on assessment of the individual patient.
Significantly fewer patients randomized to leuprorelin acetate 5% ; withdrew during treatment compared with 1 5% randomized to danazol p 05 and levitra.
2322. Greenblatt, R.B.: New Developments in Steroid Contraception. In: Proceedings of the First International Symposium on Medical and Social Problems of Birth control. edited by G. Pescetto and L. De Cecco, Minerva Medica. 309-327, 1972. Guillebaud, J., et al.: Endocrine Effects of Danazol in Menstruating Women. J. Int. Med. Res. 5 3 ; : 57-66, 1977. Holt, J.P. and Keller, 0.: Danazol Increases Serum Enzyme levels. Fert. and Ster. 41: 70-74, 1984. Hughes, M.J., Rifkind, A.B.: Danazol, a new steroidal inducer of * -aminolevulinic acid synthetase. J. Clin. Endocrinol. Metab., 52: 549-552, 1981. Lauersen, N., et al. New York, N.Y. ; : Danazol: An Antigonadotropic Agent in the Treatment of Pelvic Endometriosis. Am. J. Obst. & Gyn. 123: 742-747, 1975. Laurell, C.B. and G. Rannevik. A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens. Journal of Clinical Endocrinology and Metabolism49: 719-725, 1979. Laurell, C.B. and G. Rannevik. Comparison of plasma protein changes induced by danazol and pregnancy. Postgraduate Medical Journal 55 5 ; : 40-43, 1979. Lloyd-Jones, J.G., et al.: Danazol plasma concentration in man. J Int. Med. Res. 5 3 ; : 18-24, 1977. Luciano, A.A. et al. Effects of danazol on plasma lipid and lipoprotein levels in healthy women and in women with endometriosis. American Journal of Obstetrics and Gynecology 145: 422-426, 1983. Luciano, A.A. et al. Danazol: Endocrine consequences in healthy women. American Journal of Obstetrics and Gynecology 141: 723-727, 1981.
Biological differences between and within species require scientists to proceed with caution when interpreting the results of any experiment. Animals of different ages, sexes, developmental stages, and of different health status can all respond differently to experimental treatments. It is no surprise, then, that humans respond differently to administered pharmaceuticals than other animals. The surprise comes when scientists, physicians, and regulatory officials are willing to risk the health of patients by relying on animal experiments to predict the effects of drugs in humans--sometimes with grave results. According to some estimates, adverse drug reactions are responsible for 2.2 million hospitalizations and 106, 000 deaths annually.1 Furthermore, as many as 50 percent of FDA-approved drugs are withdrawn or relabeled due to unanticipated side effects in humans.2 A shockingly low 56 percent of known human teratogens are positive in one of six species surveyed.3 Below are a few selected examples to illustrate the dire need for better, more human-specific drug safety tests and lisinopril.
In addition, danazol appears to lower levels of high-density lipoprotein hdl ; and raise levels of low-density lipoprotein ldl.
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This article provides 1 hour of CE credit from Ascend Media's Dental Learning Systems, in association with the University of Southern California School of Dentistry and the University of Pennsylvania School of Dental Medicine, representatives of which have reviewed the articles in this issue for acceptance. Record your answers on the enclosed answer sheet or submit them on a separate sheet of paper. You may also phone your answers in to 888 ; 596-4605 or fax them to 703 ; 404-1801. Be sure to include your name, address, telephone number, and last 4 digits of your Social Security number.
Do not take contraceptive birth pills while you are taking danazol and mesterolone.
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Given these new preliminary data, and since there are alternatives to danazol for treating endometriosis, i would suggest caution in using danazol as a first-line agent, dr.
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Table 1. Drugs Most Used by Aged Medicare Beneficiaries by VA Formulary Listing and Florida Preferred Drug Listing and darvon.
The Practice Memo is published by the National Association of Chain Drug Stores NACDS ; Foundation, P.O. Box 1417-D49, Alexandria, VA 22313-1480. ISSN 1092-4272 Visit our website at nacdsfoundation K urt A. Proctor, Ph.D., R.Ph. President Edward J. Staffa, R.Ph. Editor Ronna S. Biggs, Pharm.D. Writer Stefan Merlo, Erica Nunes Contributing Writers Researchers Ellie Nigretto Designer Through educational and research initiatives, the NACDS Foundation supports programs that advance the chain pharmacy industry for the benefit of the public it serves. In addition to its own initiatives, the NACDS Foundation supports other educational and charitable causes across the country.
His program is designed to educate you on the use of generic and other low cost brand name drugs. This program is designed to help you find drugs within the same therapeutic class as a drug you may be currently taking. Most of all, this program is designed to save you money on your prescription drug costs.
The following substances may reduce the hypoglycaemic effect of repaglinide: Oral contraceptives, thiazides, corticosteroids, danazol, thyroid hormones and sympathomimetics. When these medications are administered to or withdrawn from a patient receiving repaglinide, the patient should be observed closely for changes in glycaemic control. When repaglinide is used together with other drugs that are mainly secreted by the bile like repaglinide any potential interaction should be considered. INFORMATION TO PATIENTS PACKAGE LEAFLET ; : 6. Before you use NovoNorm NovoNorm should not be used if: You have been told you are allergic to repaglinide the active ingredient in NovoNorm ; or any of the ingredients in NovoNorm You have Type 1 diabetes Insulin-Dependent Diabetes Mellitus ; Diabetic ketoacidosis You are below 12 years of age You have a severe hepatic disease You use gemfibrozil a lipid lowering drug ; as this may cause a strong enhancement and prolongation of the effect of NovoNorm; please be sure to inform your doctor if you use gemfibrozil Be sure to tell your doctor if: You have liver or kidney problems You are about to have major surgery or you have recently suffered a severe illness or infection At such times diabetic control may be lost. If any of the above applies to you, NovoNorm may not be suitable for you to use. Your doctor will advise you. Pregnancy NovoNorm should not be used if you are pregnant or you are planning to become pregnant. Breast feeding NovoNorm should not be used if you are breast-feeding. Driving and using machines You are advised to take precautions to avoid hypoglycaemia whilst driving. This is particularly important if you have reduced or absent awareness of the warning signs of hypoglycaemia or if you have frequent episodes of hypoglycaemia. The advisability of driving should be considered in these circumstances. 7. Can NovoNorm be taken with other medicines? Your NovoNorm need may change if you take other medicines. You should tell your doctor, if you take any of these medicines or any other medicines, which you are unsure about: Monoamine oxidase inhibitors Non-selective beta blocking agents used to treat high blood pressure and certain heart conditions ; Angiotensin converting enzyme ACE ; -inhibitors used to treat certain heart conditions.
Even as the Medicare program makes final plans to roll out its outpatient prescription drug coverage in less than a year, politicians are considering how it and related programs will operate. A bipartisan pair of U.S. senators introduced a bill to require Medicare to negotiate directly with drugmakers over prices, while Massachusetts' governor is urging a state program to provide seniors additional drug coverage above that offered by the federal program. CMS ISSUES PROPOSED RULE ON INCREASED PAYMENT RATES FOR LTCHS CMS published in the February 2 Federal Register 70 Fed. Reg. 5724 ; a proposed rule that would increase Medicare payment rates for long term care hospitals LTCHs ; by 3.1% for discharges on or after July 1, 2005 through June 30, 2006. CMS said it is also proposing to adopt new labor market area definitions for the purpose of geographic classification and wage indexing based upon the Core-Based Statistical Areas designated by the Office of Management and Budget using the 2000 Census Data. Comments on the proposed rule are due by March 29, 2004, and CMS said it expects to publish the final rule later this spring.
EPIDEMIOLOGICAL SURVEY OF PATIENTS WITH CONGENITAL CENTRAL HYPOVENTILATION SYNDROME: A PRELIMINARY REPORT. Gozal D, 1 Vanderlaan M, 1 Holbrook CR, 2 Wang M, 1 Tuell A1 1 ; Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 2 ; CCHS Family Network and Hartwick College, Oneonta, NY, Introduction: Congenital central hypoventilation syndrome CCHS ; is a rare lifelong disorder of respiratory control characterized by near-absent central chemosensitivity and inappropriately low ventilation, particularly during NREM sleep. Recent evidence suggests that the clinical manifestations of CCHS may in fact represent a large spectrum of neural crest dysfunction 1 ; . Traditionally, CCHS patients would be managed by mechanical ventilation via a tracheostomy. However in recent years, transition to noninvasive ventilatory support.
The treatment of endometriosis can be complex, and will obviously depend on your symptoms. It may depend on your age, and whether or not you have pain, or infertility, or both. The treatment used may generally be divided into four categories: medical, surgical, emotional social and complementary, and many women may require a combination of approaches. MEDICAL TREATMENT The aim of medical treatment is to suppress the hormonal stimulation of the endometriosis, allowing the pelvis to rest and heal. This usually involves stopping menstruation. Treatment is initially for 3-6 months, and 8090% of women notice a dramatic improvement in symptoms. The commonly used drugs which are shown in the table opposite ; , have anti-oestrogen effects ~ GnRH analogues because they induce a temporary, reversible, menopause state, and Danazol and the progestogens because they are "male" type hormones. Unfortunately, all drugs have possible side effects, but many are mild, and the commoner ones associated with these particular drugs are listed on the table. There is a great variation in the kind of side effects experienced by different women, so if one doesn't suit you, another one might. All of the drugs seem to be equally effective in controlling symptoms, though not a lot of research has been done on the oral contraceptive pill. GnRH analogues and Danazol are usually only used for a period of 6 months, because of the possible effects of prolonged low oestrogen levels. Recently however, hormone replacement therapy HRT ; in low doses, has been used in combination with the GnRH analogues, and this offers hope that it may be possible to use them for longer periods of time, but more research is needed in this area. * IT IS ALWAYS ADVISABLE TO AVOID PREGNANCY WHILE ON TREATMENT, BECAUSE OF POSSIBLE ADVERSE EFFECTS ON THE FOETUS. WHILE SOME OF THESE DRUGS ARE ACTUALLY CONTRACEPTIVE IN THEMSELVES, WITH OTHERS IT IS NECESSARY TO USE BARRIER METHODS OF CONTRACEPTION. YOU SHOUD DISCUSS THIS WITH YOUR DOCTOR. SURGICAL TREATMENT Surgical treatment of endometriosis involves removal of the endometriotic deposits, or burning them off with a laser or diathermy electrical current ; . Surgical treatment is probably superior to medical treatment for endometriosis that is deeply implanted, for endometriotic cysts, or where there is a lot of scar tissue ~ particularly if this is causing infertility. This surgery can sometimes be done at the time of the laparoscopy, i.e. "keyhole surgery". Alternatively, some women with severe symptoms, who have already had a family, or who do not wish to conceive, may opt for hysterectomy removal of the uterus ; . INFERTILITY TREATMENTS Surgery can be effective for endometriosis where damage or scarring in the fallopian tubes or ovaries is causing infertility. However, if this fails, or if the damage is inoperable, the next alternative may be IVF In Vitro Fertilisation or test-tube babies ; . For women with mild endometriosis, and where the tubes are not blocked, there is s ome controversy as to the best form of treatment. Many women will conceive spontaneously without any treatment. Otherwise fertility drugs, and eventually IVF, may be effective.
Konrobang , medical information for patients eczema eczema is an inflammation of the skin which may cause dryness, flakiness, heat, and probably most importantly, itching.
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Of India and should have held a judicial office in India for 10 years or must have practised as an advocate of a High Court or two or more such courts in succession for a similar period. Each High Court has the power to issue to any person or authority and government within its jurisdiction, direction, orders or writs including writs which are in the nature of habeas corpus, mandamus, prohibition, quo warranto and certiorari for enforcement of Fundamental Rights and for any other purpose. This power may also be exercised by any High Court exercising jurisdiction in relation to territories within which the cause of action, wholly or in part, arises for exercise of such power, even if the seat of such Government or authority or residence of such person is not within those territories. The total sanctioned strength of judges and additional judges in different High Courts is 588, against which 452 were in position as on 1 May 1999. Table 26.1 gives the seat and territorial jurisdiction of the High Courts.
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Pa.R.C.P. 1035.3 b ; . In Wolloch v. Aiken, A.2d , 2002 WL 31914696 Pa. filed December 31, 2002 ; the Court found that expert reports, submitted after the entry of summary judgment pursuant to a motion to vacate the summary judgment order were untimely. The Court reversed the order of this Court and upheld the grant of summary judgment by the trial court because the plaintiff could not establish a prima facie case without expert testimony. In dicta, the Court suggested that the proper procedure would have been to file the reports as a supplement to the response to the motion for summary judgment per Pa.R.C.P. 1035.3 b ; citing Gerrow v. John Royle & Sons, A.2d , 2002 WL 31915024 Pa. filed December 31, 2002 ; ; . 20 In Gerrow, a plurality decision of our Supreme Court with no.
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